Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5814566 | 0.81 | RECQL (0.62) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11746758 | 0.80 | RECQL (0.69) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL15430002 | 0.78 | POLB (0.62) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11746960 | 0.78 | RECQL (0.62) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11744763 | 0.78 | RECQL (0.74) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11749848 | 0.78 | RAB9A (0.68) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12961788 | 0.78 | L3MBTL1 (0.66) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11745359 | 0.77 | RECQL (0.61) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3279735 | 0.75 | CHEK1 (0.60) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL11744248 | 0.75 | PARP10 (0.66) | L3MBTL1POLBRAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130289083-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION | 2013-10-31 | — | — | US | disclosed |
| US-20130289083-A1 | IDO Inhibitors | NEWLINK GENETICS CORPORATION | 2013-10-31 | — | — | US | disclosed |
| US-20110053941-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053941-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053941-A1 | IDO Inhibitors | NEWLINK GENETICS (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053941-A1 | IDO Inhibitors | IDO1, IDO2, INMT | L3MBTL1 1178/4885POLB 2747/4885RAB9A 4328/4885 |
| US-20130289083-A1 | IDO Inhibitors | IDO1, IDO2, INMT | L3MBTL1 729/4885POLB 2709/4885RAB9A 4202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.