Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 6/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 6/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL11695225 | 0.82 | HCAR2 (0.64) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL28133862 | 0.82 | HCAR2 (0.64) | HCAR2TSHRTP53EGLN1EGLN3 | |
| Octane SCHEMBL6872110 | 0.79 | HCAR2 (0.65) | HCAR2TSHRTDP1 | |
| Octane SCHEMBL6872114 | 0.79 | HCAR2 (0.65) | HCAR2TSHRTDP1 | |
| Fumaric Acid SCHEMBL3414625 | 0.79 | HCAR2 (0.65) | HCAR2TSHRTDP1 | |
| Octane SCHEMBL2904002 | 0.79 | HCAR2 (0.65) | HCAR2TSHRTDP1 | |
| Nonane SCHEMBL8691965 | 0.79 | HCAR2 (0.65) | HCAR2TSHRTDP1 | |
| Fumaric Acid SCHEMBL3414623 | 0.79 | HCAR2 (0.65) | HCAR2TSHRTDP1 | |
| Decane SCHEMBL9668679 | 0.79 | HCAR2 (0.65) | HCAR2TSHRTDP1 | |
| Octane SCHEMBL8193217 | 0.79 | HCAR2 (0.65) | HCAR2TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563675-B2 | Curable compositions composed of silanes with two hydrolyzable groups | HENKEL AG & CO. KGAA (DE) | 2013-10-22 | — | — | US | disclosed |
| US-20120059130-A1 | CURABLE COMPOSITIONS CONSISTING OF SILANES WITH THREE HYDROLYSABLE GROUPS | HENKEL AG & CO. KGAA (DE) | 2012-03-08 | — | — | US | disclosed |
| US-20100216950-A1 | CURABLE COMPOSITIONS CONSISTING OF SILANES WITH THREE HYDROLYSABLE GROUPS | HENKEL AG & CO. KGAA (DE) | 2010-08-26 | — | — | US | disclosed |
| US-20100204387-A1 | CURABLE COMPOSITIONS COMPOSED OF SILANES WITH TWO HYDROLYZABLE GROUPS | HENKEL AG & CO. KGAA (DE) | 2010-08-12 | — | — | US | disclosed |