Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCRL2 | O00421 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | BMI1 | P35226 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30502558 | 1.00 | METAP2 (0.41) | METAP2GRM5KIF11CYP11B2BACE1 | |
| SCHEMBL12032472 | 0.80 | KIF11 (0.39) | METAP2GRM5KIF11CYP11B2BACE1 | |
| SCHEMBL9998302 | 0.79 | METAP2 (0.41) | METAP2GRM5KIF11BACE1CCNE2 | |
| SCHEMBL9999438 | 0.79 | METAP2 (0.41) | METAP2GRM5KIF11BACE1CCNE2 | |
| SCHEMBL9998468 | 0.79 | KDM4E (0.45) | METAP2GRM5KIF11BACE1CCNE2 | |
| SCHEMBL8404450 | 0.76 | CYP1A2 (0.42) | GRM5BACE1MEN1KMT2AKDM4E | |
| SCHEMBL18630340 | 0.73 | TYMS (0.37) | MEN1KMT2AKDM4E | |
| SCHEMBL14477435 | 0.72 | KDM4E (0.41) | GRM5KIF11CYP11B2BACE1CCNE2 | |
| SCHEMBL27902579 | 0.71 | CCRL2 (0.44) | KIF11SOS1CCRL2TRPV1KDM4E | |
| SCHEMBL27920310 | 0.71 | BACE1 (0.50) | METAP2KIF11BACE1CHUKMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9062048-B2 | Cyclohexyl-azetidinyl antagonists of CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2015-06-23 | — | — | US | disclosed |
| US-8518969-B2 | Cyclohexyl-azetidinyl antagonists of CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2013-08-27 | — | — | US | disclosed |