SCHEMBL15214878

SCHEMBL15214878

COc1ccc(S(=O)(=O)ON=C(C#N)c2cccc(C(C#N)=NOS(=O)(=O)c3ccc(OC)cc3)c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.43
MEN1 O00255 2/20 0.43
ATM Q13315 1/20 0.42
EP300 Q09472 1/20 0.41
KAT2A Q92830 1/20 0.41
KAT2B Q92831 1/20 0.41
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
TCF4 P15884 1/20 0.41
CTNNB1 P35222 1/20 0.41
ALDH1A1 P00352 3/20 0.40
STS P08842 1/20 0.40
CYP19A1 P11511 1/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39
TUBA3C P0DPH7 1/20 0.39
TUBA1B P68363 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10084010 0.92 MAPT (0.39) KMT2AMEN1ATMEP300KAT2A
SCHEMBL12727038 0.91 IDO1 (0.40) KMT2AMEN1ATMEP300KAT2A
SCHEMBL5918261 0.89 EP300 (0.45) EP300KAT2AKAT2BTDP1ALDH1A1
SCHEMBL5918260 0.89 EP300 (0.45) EP300KAT2AKAT2BTDP1ALDH1A1
SCHEMBL11003138 0.89 NPC1 (0.46) KMT2AMEN1ATMSMN1; SMN2ALDH1A1
SCHEMBL11003125 0.89 NPC1 (0.46) KMT2AMEN1ATMSMN1; SMN2ALDH1A1
SCHEMBL29645031 0.89 PKM (0.43) KMT2AMEN1ATMEP300KAT2A
SCHEMBL10083960 0.87 TCF4 (0.38) KMT2AMEN1LMNAHTTSMN1; SMN2
SCHEMBL7781708 0.86 PDE4A (0.47) KMT2AMEN1LMNAALDH1A1GAA
SCHEMBL7781706 0.86 PDE4A (0.47) KMT2AMEN1LMNAALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8519073-B2 Compound and polymeric compound TOKYO OHKA KOGYO CO., LTD. (JP) 2013-08-27 US disclosed