Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20210374 | 1.00 | POLB (0.48) | POLBXIAPCTRB1KMT2AMEN1 | |
| SCHEMBL29350646 | 1.00 | POLB (0.48) | POLBXIAPCTRB1KMT2AMEN1 | |
| SCHEMBL22804000 | 1.00 | POLB (0.48) | POLBXIAPCTRB1KMT2AMEN1 | |
| SCHEMBL30963662 | 0.97 | POLB (0.51) | POLBXIAPCTRB1KMT2AMEN1 | |
| SCHEMBL25404023 | 0.89 | CTRB1 (0.48) | CTRB1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL29211787 | 0.89 | CTRB1 (0.48) | CTRB1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL25404019 | 0.89 | CTRB1 (0.48) | CTRB1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL31500753 | 0.88 | CTRB1 (0.47) | POLBCTRB1KMT2AL3MBTL1TSHR | |
| SCHEMBL29413336 | 0.85 | CTRB1 (0.49) | CTRB1KMT2AL3MBTL1TSHRALDH1A1 | |
| SCHEMBL30317756 | 0.85 | CTRB1 (0.49) | CTRB1KMT2AL3MBTL1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11229711-B2 | Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use | Magenta Therapeutics, Inc. (US) | 2022-01-25 | — | — | US | disclosed |
| US-20160367699-A1 | NOVEL LINKERS FOR ANTIBODY-DRUG CONJUGATES AND RELATED COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SENSEI BIOTHERAPEUTICS, INC. | 2016-12-22 | — | — | US | disclosed |
| US-20160303247-A1 | Antibody-Drug Conjugates and Related Compounds, Compositions, and Methods | IGENICA BIOTHERAPEUTICS, INC. (US) | 2016-10-20 | — | — | US | disclosed |
| US-20140363454-A1 | Antibody-Drug Conjugates, Compositions and Methods of Use | IGENICA BIOTHERAPEUTICS, INC. (US) | 2014-12-11 | — | — | US | disclosed |
| WO-2014197854-A1 | NOVEL LINKERS FOR ANTIBODY-DRUG CONJUGATES AND RELATED COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | IGENICA BIOTHERAPEUTICS, INC. (US) | 2014-12-11 | — | — | WO | disclosed |
| US-20130224228-A1 | Antibody-Drug Conjugates and Related Compounds, Compositions, and Methods | IGENICA, INC. (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140363454-A1 | Antibody-Drug Conjugates, Compositions and Methods of Use | SDCBP, CD81, DSTN | POLB 3968/4885XIAP 509/4885CTRB1 1879/4885 |
| US-11229711-B2 | Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use | CLSPN, SDCBP, DCLRE1A | POLB 2885/4885XIAP 74/4885CTRB1 3345/4885 |
| US-20160303247-A1 | Antibody-Drug Conjugates and Related Compounds, Compositions, and Methods | SDCBP, CD81, NGLY1 | POLB 4383/4885XIAP 698/4885CTRB1 1824/4885 |
| US-20160367699-A1 | NOVEL LINKERS FOR ANTIBODY-DRUG CONJUGATES AND RELATED COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | SDCBP, DCLRE1A, BCR | POLB 3166/4885XIAP 63/4885CTRB1 3536/4885 |
| US-20130224228-A1 | Antibody-Drug Conjugates and Related Compounds, Compositions, and Methods | SDCBP, CD81, NGLY1 | POLB 4383/4885XIAP 698/4885CTRB1 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.