Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | MGLL | Q99685 | 4/20 | 0.44 |
| ▸ | FAAH | O00519 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26111142 | 1.00 | PTGS1 (0.46) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL6753087 | 0.94 | PTGS1 (0.45) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL18995821 | 0.94 | PTGS1 (0.51) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL13113726 | 0.91 | PTGS1 (0.55) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL14984835 | 0.89 | PTGS1 (0.49) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL12848812 | 0.87 | ALDH1A1 (0.44) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL20179428 | 0.86 | PTGS1 (0.49) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL932316 | 0.86 | PTGS1 (0.66) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL12132672 | 0.86 | PTGS1 (0.57) | PTGS1PTGS2MGLLFAAHALDH1A1 | |
| SCHEMBL15297018 | 0.86 | PTGS1 (0.66) | PTGS1PTGS2MGLLFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783612-B2 | CX3CR1-binding polypeptides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-10-10 | — | — | US | disclosed |
| US-20170247475-A1 | BISPECIFIC BINDING MOLECULES BINDING TO VEGF AND ANG2 | BOEHRINGER INGELHEIM INT (DE) | 2017-08-31 | — | — | US | disclosed |
| US-9211330-B2 | A-beta binding polypeptides | ABLYNX N.V. (BE) | 2015-12-15 | — | — | US | disclosed |
| US-9035029-B2 | CX3CR1-binding polypeptides comprising immunoglobulin single variable domains | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-05-19 | — | — | US | disclosed |
| US-20140120095-A1 | BISPECIFIC BINDING MOLECULES FOR ANTI-ANGIOGENESIS THERAPY | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-01 | — | — | US | disclosed |
| US-20140030275-A1 | A-BETA BINDING POLYPEPTIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-30 | — | — | US | disclosed |
| US-20130224224-A1 | CX3CR1-BINDING POLYPEPTIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140030275-A1 | A-BETA BINDING POLYPEPTIDES | APBA1, APP, BTN3A1 | PTGS1 3546/4885PTGS2 4069/4885MGLL 3930/4885 |
| US-20170247475-A1 | BISPECIFIC BINDING MOLECULES BINDING TO VEGF AND ANG2 | KDR, VEGFA, FLT4 | PTGS1 2509/4885PTGS2 924/4885MGLL 3614/4885 |
| US-20140120095-A1 | BISPECIFIC BINDING MOLECULES FOR ANTI-ANGIOGENESIS THERAPY | FLT4, VEGFA, KDR | PTGS1 1321/4885PTGS2 2072/4885MGLL 3961/4885 |
| US-20130224224-A1 | CX3CR1-BINDING POLYPEPTIDES | CX3CR1, CXCR3, CCL2 | PTGS1 3824/4885PTGS2 4147/4885MGLL 2751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.