Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | AGXT | P21549 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14340523 | 0.80 | FFAR1 (0.41) | F2MEN1KMT2A | |
| SCHEMBL158382 | 0.80 | CHRM2 (0.38) | MEN1KMT2ATAAR1IDO1AGXT | |
| SCHEMBL15219801 | 0.77 | TAAR1 (0.55) | TAAR1IDO1AGXTGRIN1GRIN2B | |
| SCHEMBL14730561 | 0.77 | TSHR (0.44) | MEN1KMT2A | |
| SCHEMBL28286056 | 0.77 | PNMT (0.44) | TAAR1IDO1AGXT | |
| SCHEMBL10835184 | 0.76 | ALDH1A1 (0.39) | MEN1KMT2AIDO1AGXTCYP1A2 | |
| SCHEMBL28114320 | 0.75 | IDO1 (0.41) | F2MEN1KMT2AIDO1AGXT | |
| SCHEMBL26009 | 0.74 | KMT2A (0.41) | MEN1KMT2ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL20350466 | 0.72 | TAAR1 (0.49) | TAAR1IDO1AGXT | |
| SCHEMBL23776528 | 0.71 | HRH3 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |