Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19171338 | 0.82 | NPC1 (0.57) | NPC1RAB9AMAPTSMN1; SMN2KDM4C | |
| SCHEMBL15224191 | 0.80 | RAB9A (0.45) | NPC1RAB9AMAPTSMN1; SMN2EPHX1 | |
| SCHEMBL20017302 | 0.80 | NPC1 (0.55) | NPC1RAB9AMAPTSMN1; SMN2KDM4C | |
| SCHEMBL22753138 | 0.78 | NPC1 (0.42) | NPC1RAB9AMAPTSMN1; SMN2KDM4C | |
| SCHEMBL19164342 | 0.78 | NPC1 (0.53) | NPC1RAB9AMAPTSMN1; SMN2KDM4C | |
| SCHEMBL19171376 | 0.78 | EPHX1 (0.57) | NPC1RAB9AMAPTSMN1; SMN2KDM4C | |
| SCHEMBL18902713 | 0.78 | EPHX1 (0.49) | NPC1RAB9AMAPTSMN1; SMN2KDM4C | |
| SCHEMBL19115237 | 0.76 | MAPT (0.45) | NPC1RAB9AMAPTSMN1; SMN2KDM4C | |
| SCHEMBL7816137 | 0.76 | KDM4C (0.67) | NPC1RAB9AMAPTSMN1; SMN2KDM4C | |
| SCHEMBL19171947 | 0.76 | EPHX1 (0.60) | NPC1RAB9AMAPTSMN1; SMN2KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2439202-B1 | INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | SALVAT LAB SA (ES) | 2016-04-20 | — | — | EP | disclosed |
| US-8524894-B2 | Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1 | LABORATORIOS SALVAT, S.A. (ES) | 2013-09-03 | — | — | US | disclosed |