Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733557 | 0.83 | NPC1 (0.44) | MAPTNPC1RAB9ASMN1; SMN2CACNA1H | |
| SCHEMBL13853869 | 0.82 | KEAP1 (0.36) | MAPTSMN1; SMN2CACNA1HKDM4CEPHX1 | |
| SCHEMBL24535362 | 0.80 | CACNA1H (0.35) | CACNA1HALDH1A1TSHR | |
| SCHEMBL19171338 | 0.79 | NPC1 (0.57) | MAPTNPC1RAB9ASMN1; SMN2CACNA1H | |
| SCHEMBL8070389 | 0.78 | LDHA (0.34) | MAPTSMN1; SMN2CACNA1HALDH1A1TSHR | |
| SCHEMBL20017302 | 0.77 | NPC1 (0.55) | MAPTNPC1RAB9ASMN1; SMN2CACNA1H | |
| SCHEMBL15224154 | 0.76 | NPC1 (0.47) | MAPTNPC1RAB9ASMN1; SMN2CACNA1H | |
| SCHEMBL13644760 | 0.75 | NPC1 (0.50) | MAPTNPC1RAB9ASMN1; SMN2CACNA1H | |
| SCHEMBL19171376 | 0.74 | EPHX1 (0.57) | MAPTNPC1RAB9ASMN1; SMN2CACNA1H | |
| SCHEMBL19164342 | 0.74 | NPC1 (0.53) | MAPTNPC1RAB9ASMN1; SMN2CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170197986-A1 | DIHYDROPYRIMIDO LOOP DERIVATIVE AS HBV INHIBITOR | MEDSHINE DISCOVERY INC. (CN) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197986-A1 | DIHYDROPYRIMIDO LOOP DERIVATIVE AS HBV INHIBITOR | TMBIM6, HAVCR2, HDGF | MAPT 2073/4885NPC1 856/4885RAB9A 1374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.