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SCHEMBL1522545

SCHEMBL1522545

CCOC(=O)c1c(O)c2cccnc2n(Cc2ccccc2)c1=O

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.62
▸ KMT2A Q03164 1/20 0.62
▸ KDM4E B2RXH2 5/20 0.60
▸ CNR2 P34972 5/20 0.59
▸ CNR1 P21554 2/20 0.59
▸ PTGDR2 Q9Y5Y4 1/20 0.55
▸ LMNA P02545 3/20 0.53
▸ ALDH1A1 P00352 5/20 0.52
▸ RECQL P46063 1/20 0.52
▸ MAPT P10636 2/20 0.51
▸ HTT P42858 1/20 0.51
▸ GAA P10253 2/20 0.49
▸ PKM P14618 1/20 0.49
▸ HPGD P15428 1/20 0.48
▸ TSHR P16473 1/20 0.48
▸ CASP1 P29466 1/20 0.48
▸ CASP7 P55210 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7836812 0.92 PTGDR2 (0.55) MEN1KMT2AKDM4ECNR2CNR1
SCHEMBL24002746 0.91 CNR2 (0.65) MEN1KMT2AKDM4ECNR2CNR1
SCHEMBL4849772 0.90 PTGDR2 (0.58) MEN1KMT2AKDM4ECNR2CNR1
SCHEMBL7822748 0.89 KDM4E (0.60) MEN1KMT2AKDM4ECNR2CNR1
SCHEMBL4851227 0.89 MEN1 (0.62) MEN1KMT2AKDM4ECNR2CNR1
SCHEMBL2088819 0.89 CNR2 (0.55) MEN1KMT2AKDM4ECNR2CNR1
SCHEMBL2087811 0.89 PTGDR2 (0.58) MEN1KMT2AKDM4ECNR2CNR1
SCHEMBL3514492 0.88 PTGDR2 (0.58) MEN1KMT2AKDM4ECNR2CNR1
SCHEMBL8139224 0.88 KDM4E (0.66) MEN1KMT2AKDM4ECNR2CNR1
SCHEMBL2088737 0.86 KDM4E (0.52) MEN1KMT2AKDM4ECNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0784622-B1 NAPHTHYRIDINONE DERIVATIVES KNOLL GMBH (DE) 2001-11-21 — — EP claimed
EP-2361913-A1 Anti-infective agents Abbott Laboratories (US) 2011-08-31 — — EP disclosed
US-7902203-B2 Anti-infective agents ABBOTT LABORATORIES, INC. (US) 2011-03-08 — — US disclosed
EP-1560827-B1 ANTI-INFECTIVE AGENTS ABBOTT LAB (US) 2010-12-29 — — EP disclosed
US-20100056563-A1 NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS MERCK SHARP & DOHME CORP. 2010-03-04 — — US disclosed
US-20100056563-A1 NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS MERCK SHARP & DOHME CORP. 2010-03-04 — — US disclosed
EP-2136810-A1 NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS Merck & Co., Inc. (US) 2009-12-30 — — EP disclosed
WO-2008130527-A1 NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS MERCK & CO., INC. (US) 2008-10-30 — — WO disclosed
WO-2008130527-A1 NOVEL 1,8-NAPHTHYRIDINE COMPOUNDS MERCK & CO., INC. (US) 2008-10-30 — — WO disclosed
US-7361760-B2 Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases AVANIR PHARMACEUTICALS (US) 2008-04-22 — — US disclosed
US-20050124604-A1 Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases AVANIR PHARMACEUTICALS, INC. 2005-06-09 — — US disclosed
US-20050075331-A1 Anti-infective agents ABBOTT LABORATORIES 2005-04-07 — — US disclosed
WO-2005021546-A1 SUBSTITUTED NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND THEIR USE IN THE TREATMENT OF HUMAN DISEASES AVANIR PHARMACEUTICALS (US) 2005-03-10 — — WO disclosed
US-20040167123-A1 Anti-infective agents ABBVIE INC. 2004-08-26 — — US disclosed
US-20040162285-A1 Anti-infective agents ABBOTT LABORATORIES 2004-08-19 — — US disclosed
WO-2004041818-A1 ANTI-INFECTIVE AGENTS ABBOTT LABORATORIES (US) 2004-05-21 — — WO disclosed
US-20040097492-A1 Anti-infective agents ABBOTT LABORATORIES 2004-05-20 — — US disclosed
US-20040087577-A1 Anti-infective agents ABBOTT LABORATORIES 2004-05-06 — — US disclosed
EP-0784622-B1 NAPHTHYRIDINONE DERIVATIVES KNOLL GMBH (DE) 2001-11-21 — — EP disclosed
US-5854257-A Naphthyridinone derivatives KNOLL AKTIENGESELLSCHAFT (DE) 1998-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040097492-A1 Anti-infective agents POLR1C, RPL5, POLB MEN1 4676/4885KMT2A 4668/4885KDM4E 4352/4885
US-20040162285-A1 Anti-infective agents POLR1C, RPL5, POLB MEN1 4676/4885KMT2A 4668/4885KDM4E 4352/4885
US-20050124604-A1 Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases MIF, MSR1, SLC11A2 MEN1 1559/4885KMT2A 4090/4885KDM4E 3601/4885
US-20040167123-A1 Anti-infective agents SERPINB1, CYP51A1, ZC3HAV1 MEN1 4453/4885KMT2A 4623/4885KDM4E 4075/4885
US-20050075331-A1 Anti-infective agents RPL35, POLI, POLRMT MEN1 4797/4885KMT2A 4532/4885KDM4E 3897/4885
US-20040087577-A1 Anti-infective agents POLR1C, RPL5, POLB MEN1 4676/4885KMT2A 4668/4885KDM4E 4352/4885
US-20100056563-A1 NOVEL 1.8-NAPHTHYRIDINE COMPOUNDS HIF1AN, HIF1A, EGLN2 MEN1 3033/4885KMT2A 348/4885KDM4E 179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.