Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855838 | 0.81 | MAPT (0.41) | LMNAMAPK1HPGDHTTCYP1A2 | |
| SCHEMBL23409171 | 0.80 | MAPT (0.51) | LMNAMAPK1HPGDALDH1A1HTT | |
| SCHEMBL30070834 | 0.80 | MAPT (0.51) | LMNAMAPK1HPGDALDH1A1HTT | |
| SCHEMBL15684529 | 0.77 | KMT2A (0.56) | LMNAMAPK1HPGDALDH1A1HTT | |
| SCHEMBL7661858 | 0.77 | GAA (0.62) | LMNAMAPK1ALDH1A1HTTMAPT | |
| SCHEMBL10476884 | 0.76 | LMNA (0.69) | LMNAMAPK1HPGDALDH1A1HTT | |
| SCHEMBL28622015 | 0.75 | LTB4R (0.47) | LMNAMAPK1HPGDALDH1A1CYP1A2 | |
| SCHEMBL30785064 | 0.75 | PTPN11 (0.52) | MAPK1MAPTPOLBKDM4E | |
| SCHEMBL10293784 | 0.75 | LMNA (0.68) | LMNAMAPK1HPGDALDH1A1HTT | |
| SCHEMBL28081760 | 0.74 | ALDH1A1 (0.47) | LMNAMAPK1HPGDALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1642880-B1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |