SCHEMBL15225947

SCHEMBL15225947

COc1cccc(-c2cc(C(=O)c3ccc(OC)c(-c4cccc(OC)c4)c3)ccc2OC)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.58
HSP90AB1 P08238 2/20 0.58
SYK P43405 1/20 0.57
HDAC4 P56524 1/20 0.56
HDAC2 Q92769 1/20 0.56
HDAC8 Q9BY41 1/20 0.56
ALDH1A1 P00352 3/20 0.54
GAA P10253 1/20 0.54
CYP1A2 P05177 3/20 0.53
CYP2C19 P33261 3/20 0.53
CYP3A4 P08684 2/20 0.53
CYP2C9 P11712 2/20 0.53
TSHR P16473 1/20 0.53
HTT P42858 2/20 0.50
MAPT P10636 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
TUBB4A P04350 1/20 0.49
TUBB P07437 1/20 0.49
TUBA3C P0DPH7 1/20 0.49
TUBA1B P68363 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1607173 0.90 LMNA (0.62) HSP90AA1HSP90AB1SYKHDAC4HDAC2
SCHEMBL29651459 0.90 LMNA (0.62) HSP90AA1HSP90AB1SYKHDAC4HDAC2
SCHEMBL6934114 0.88 HSP90AA1 (0.58) HSP90AA1HSP90AB1SYKHDAC4HDAC2
SCHEMBL29460667 0.88 PARP1 (0.62) HSP90AA1HSP90AB1SYKHDAC4HDAC2
SCHEMBL19519568 0.80 HSP90AA1 (0.56) HSP90AA1HSP90AB1SYKHDAC4HDAC2
SCHEMBL13117447 0.80 TRAP1 (0.55) HSP90AA1HSP90AB1SYKALDH1A1TSHR
SCHEMBL4824157 0.80 CYP1A2 (0.73) ALDH1A1GAACYP1A2CYP2C19CYP3A4
SCHEMBL15654606 0.79 ALDH1A1 (0.63) SYKHDAC8ALDH1A1GAACYP1A2
SCHEMBL1406821 0.78 LMNA (0.56) SYKALDH1A1GAACYP1A2CYP2C19
SCHEMBL30112655 0.78 CYP3A4 (0.69) HDAC4HDAC2HDAC8ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1642880-B1 HSP90 FAMILY PROTEIN INHIBITORS KYOWA HAKKO KIRIN CO LTD (JP) 2013-09-04 EP claimed