Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL15225846 | 0.93 | TSHR (0.45) | TSHRCA12CA7CA14SMN1; SMN2 | |
| SCHEMBL8125415 | 0.84 | CHRM5 (0.41) | TSHRL3MBTL1POLBKDM4ELMNA | |
| SCHEMBL13013205 | 0.82 | GRM5 (0.39) | TSHRSMN1; SMN2L3MBTL1POLBLMNA | |
| SCHEMBL14836906 | 0.78 | CA1 (0.42) | TSHRL3MBTL1POLBKDM4EALDH1A1 | |
| SCHEMBL27075429 | 0.78 | JAK2 (0.41) | TSHRL3MBTL1GRM5 | |
| SCHEMBL20600247 | 0.77 | KMO (0.39) | TSHRSMN1; SMN2L3MBTL1POLBKDM4E | |
| SCHEMBL626217 | 0.76 | JAK2 (0.42) | TSHRPOLBGRM5 | |
| SCHEMBL27034818 | 0.76 | JAK2 (0.42) | TSHRSMN1; SMN2L3MBTL1LMNAMAPK1 | |
| SCHEMBL13993576 | 0.75 | ALDH1A1 (0.43) | TSHRL3MBTL1POLBKDM4ELMNA | |
| SCHEMBL8280866 | 0.75 | HSD11B1 (0.46) | TSHRL3MBTL1POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1616859-B1 | Substituted cyclohexyl carboxylic acid compounds | SEIKAGAKU KOGYO CO LTD (JP) | 2013-09-04 | — | — | EP | claimed |