Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Mazaticol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.39 |
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 16/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 13/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 11/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mazaticol SCHEMBL34619 | 0.84 | CHRM3 (0.51) | ADRA1ACHRM3CHRM2CHRM1CHRM4 | |
| Mazaticol SCHEMBL182361 | 0.83 | CHRM3 (0.50) | ADRA1ACHRM3CHRM2CHRM1CHRM4 | |
| Mazaticol SCHEMBL17747972 | 0.83 | CHRM3 (0.50) | ADRA1ACHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL4886970 | 0.72 | CHRM3 (0.60) | ADRA1ALMNABLMTDP1CHRM3 | |
| SCHEMBL4886984 | 0.72 | CHRM3 (0.60) | ADRA1ALMNABLMTDP1CHRM3 | |
| SCHEMBL4886957 | 0.72 | CHRM3 (0.60) | ADRA1ALMNABLMTDP1CHRM3 | |
| Mazaticol SCHEMBL28086106 | 0.69 | CHRM3 (0.34) | ADRA1ACHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL1900207 | 0.65 | CHRM3 (0.60) | ADRA1ACHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL16742011 | 0.65 | CHRM3 (0.60) | ADRA1ACHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL14472825 | 0.65 | CHRM3 (0.60) | ADRA1ACHRM3CHRM2CHRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3563841-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | Pharnext (FR) | 2019-11-06 | — | — | EP | disclosed |
| EP-3185859-B1 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2019-07-17 | — | — | EP | disclosed |
| US-10342768-B2 | Therapeutic approaches for treating Parkinson's disease | PHARNEXT (FR) | 2019-07-09 | — | — | US | disclosed |
| US-10010515-B2 | Therapeutic approaches for treating Parkinson's disease | PHARNEXT (FR) | 2018-07-03 | — | — | US | disclosed |
| US-20170273919-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2017-09-28 | — | — | US | disclosed |
| EP-2819663-B1 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2017-07-05 | — | — | EP | disclosed |
| EP-3185859-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | Pharnext (FR) | 2017-07-05 | — | — | EP | disclosed |
| US-20160193163-A1 | THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2016-07-07 | — | — | US | disclosed |
| WO-2016030522-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2016-03-03 | — | — | WO | disclosed |
| US-9248111-B2 | Therapeutic approaches for treating parkinson's disease | PHARNEXT (FR) | 2016-02-02 | — | — | US | disclosed |
| CN-104487062-A | Novel therapeutic methods for treating parkinson's disease | PHARNEXT | 2015-04-01 | — | — | CN | disclosed |
| EP-2819663-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | Pharnext (FR) | 2015-01-07 | — | — | EP | disclosed |
| US-20140371229-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2014-12-18 | — | — | US | disclosed |
| WO-2013127918-A1 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2013-09-06 | — | — | WO | disclosed |