Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2066409 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL18377855 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL13103451 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL24156797 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL21808338 | 0.74 | EPHX2 (0.57) | SMN1; SMN2TP53ALDH1A1POLBGAA | |
| SCHEMBL2067169 | 0.73 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL2067782 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL10203210 | 0.69 | SMN1; SMN2 (0.52) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL19116361 | 0.69 | ERCC5 (0.49) | SMN1; SMN2TP53ALDH1A1MEN1KMT2A | |
| SCHEMBL16532120 | 0.69 | GSK3A (0.44) | SMN1; SMN2ALDH1A1POLBMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9434743-B2 | Indazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-09-06 | — | — | US | disclosed |
| US-20150005232-A1 | INDAZOLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (US) | 2015-01-01 | — | — | US | disclosed |
| WO-2013130855-A1 | INDAZOLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005232-A1 | INDAZOLE DERIVATIVES | GPR119, INSR, INSRR | SMN1; SMN2 1621/4885TP53 2419/4885ALDH1A1 511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.