Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.56 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 2/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15244897 | 1.00 | KCNH2 (0.56) | KCNH2CACNA1CASIC3CNR2GPR119 | |
| SCHEMBL23601164 | 0.90 | KCNH2 (0.57) | KCNH2CACNA1CASIC3CNR2GPR119 | |
| SCHEMBL3442195 | 0.89 | GPR119 (0.59) | KCNH2CACNA1CASIC3GPR119HDAC3 | |
| SCHEMBL24721023 | 0.86 | TLR9 (0.53) | KCNH2CACNA1CASIC3CNR2GPR119 | |
| SCHEMBL12911540 | 0.84 | HDAC3 (0.58) | KCNH2CACNA1CASIC3GPR119HDAC3 | |
| SCHEMBL19497006 | 0.84 | NTRK1 (0.53) | KCNH2CACNA1CASIC3CNR2GPR119 | |
| Hydrochloric Acid SCHEMBL943217 | 0.83 | HDAC3 (0.57) | KCNH2CACNA1CASIC3GPR119HDAC3 | |
| Hydrochloric Acid SCHEMBL20293639 | 0.83 | HDAC2 (0.55) | KCNH2CACNA1CASIC3GPR119HDAC3 | |
| SCHEMBL10198619 | 0.81 | TLR9 (0.50) | KCNH2CACNA1CASIC3CNR2GPR119 | |
| SCHEMBL12911533 | 0.81 | GPR119 (0.58) | KCNH2CACNA1CASIC3CNR2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150094294-A1 | COMPOUNDS AND METHODS FOR TREATING MALARIA | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-04-02 | — | — | US | disclosed |
| US-20150094294-A1 | COMPOUNDS AND METHODS FOR TREATING MALARIA | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-04-02 | — | — | US | disclosed |
| WO-2013130738-A1 | COMPOUNDS AND METHODS FOR TREATING MALARIA | POLYMEDIX, INC. (US) | 2013-09-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150094294-A1 | COMPOUNDS AND METHODS FOR TREATING MALARIA | PC, CPS1, GLS2 | KCNH2 2717/4885CACNA1C 2184/4885ASIC3 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.