Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | PKLR | P30613 | 1/20 | 0.36 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849624 | 0.89 | PKM (0.49) | PKMMAPTNPC1RAB9AKDM1A | |
| SCHEMBL25513582 | 0.80 | AKT1 (0.40) | MAPTKDM4EHTTATMCOXFA4 | |
| SCHEMBL21556102 | 0.79 | MAPT (0.38) | PKMMAPTNPC1RAB9AKDM4E | |
| SCHEMBL25513573 | 0.79 | AKT1 (0.42) | PKMKDM4EHTTATMALDH1A1 | |
| SCHEMBL12035985 | 0.78 | MAPT (0.41) | MAPTKDM4EHTTATMMAOB | |
| SCHEMBL7326936 | 0.77 | KDM1A (0.42) | MAPTNPC1RAB9AKDM4EKDM1A | |
| SCHEMBL14449323 | 0.76 | AKT1 (0.36) | PKMMAPTNPC1RAB9AKDM4E | |
| SCHEMBL7606467 | 0.75 | PKM (0.40) | PKMMAPTNPC1RAB9AKDM4E | |
| SCHEMBL14449820 | 0.74 | KDM4E (0.36) | PKMMAPTNPC1RAB9AKDM4E | |
| SCHEMBL10434159 | 0.73 | KDM4E (0.37) | PKMMAPTNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013137479-A1 | DECAHYDROQUINOXALINE DERIVATIVES AND ANALOGS THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-09-19 | — | — | WO | disclosed |