Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | SELE | P16581 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15280629 | 0.87 | KDM4C (0.43) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL15271371 | 0.81 | KDM4C (0.39) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL23388034 | 0.80 | KDM4C (0.41) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL29749617 | 0.80 | KDM4C (0.41) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL31394558 | 0.79 | NOS3 (0.38) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL30486563 | 0.75 | KDM4C (0.47) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL25229073 | 0.75 | KDM4C (0.47) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL17649327 | 0.74 | L3MBTL1 (0.43) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL25281689 | 0.74 | ALDH1A1 (0.41) | KDM4CL3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL30486583 | 0.74 | ALDH1A1 (0.41) | KDM4CL3MBTL1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110891951-B | Compounds of formula (I) | 谢菲尔德大学 | 2024-08-20 | — | — | CN | disclosed |
| CN-110891951-A | Compound (I) | 谢菲尔德大学 | 2020-03-17 | — | — | CN | disclosed |
| US-9487523-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-11-08 | — | — | US | disclosed |
| US-9487523-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20150038707-A1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-02-05 | — | — | US | disclosed |
| US-20150038707-A1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-02-05 | — | — | US | disclosed |
| WO-2013138418-A2 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038707-A1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | CALCRL, CALCR, GRPR | KDM4C 3517/4885L3MBTL1 1470/4885NPC1 1364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.