Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAMP1 | O60894 | 5/20 | 0.48 |
| ▸ | CALCRL | Q16602 | 5/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20664272 | 1.00 | RAMP1 (0.48) | RAMP1CALCRLMAOBKDM1ASCN9A | |
| SCHEMBL30683667 | 1.00 | RAMP1 (0.48) | RAMP1CALCRLMAOBKDM1ASCN9A | |
| SCHEMBL20664219 | 1.00 | RAMP1 (0.48) | RAMP1CALCRLMAOBKDM1ASCN9A | |
| SCHEMBL26619202 | 0.89 | MDM2 (0.42) | RAMP1CALCRL | |
| SCHEMBL31511788 | 0.89 | MDM2 (0.42) | RAMP1CALCRL | |
| SCHEMBL16658947 | 0.89 | MAOB (0.48) | RAMP1CALCRLMAOBKDM1ASIGMAR1 | |
| SCHEMBL15280637 | 0.88 | CALCRL (0.50) | RAMP1CALCRLMAOBKDM1ASCN9A | |
| SCHEMBL20664220 | 0.88 | CALCRL (0.50) | RAMP1CALCRLMAOBKDM1ASCN9A | |
| SCHEMBL35210147 | 0.88 | CALCRL (0.50) | RAMP1CALCRLMAOBKDM1ASCN9A | |
| SCHEMBL30683670 | 0.87 | CALCRL (0.51) | RAMP1CALCRLKDM1ASIGMAR1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4737458-A2 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | Merck Sharp & Dohme LLC (US) | 2026-05-06 | — | — | EP | disclosed |
| WO-2024150250-A1 | A PROCESS FOR THE PREPARATION OF ATOGEPANT AND ITS INTERMEDIATES | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2024-07-18 | — | — | WO | disclosed |
| US-9850246-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-12-26 | — | — | US | disclosed |
| US-9487523-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20160130273-A1 | Process for Making CGRP Receptor Antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-05-12 | — | — | US | disclosed |
| US-9174989-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20150112067-A1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-04-23 | — | — | US | disclosed |
| WO-2013138418-A2 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150112067-A1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | CCKBR, BDKRB2, CALCR | RAMP1 19/4885CALCRL 7/4885MAOB 185/4885 |
| US-20160130273-A1 | Process for Making CGRP Receptor Antagonists | CALCR, CALCRL, VIPR1 | RAMP1 6/4885CALCRL 2/4885MAOB 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.