Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 6/20 | 0.50 |
| ▸ | RAMP1 | O60894 | 5/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.40 |
| ▸ | CCKBR | P32239 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35210147 | 1.00 | CALCRL (0.50) | CALCRLRAMP1SCN9ACCKBRKMT2A | |
| SCHEMBL20664220 | 1.00 | CALCRL (0.50) | CALCRLRAMP1SCN9ACCKBRKMT2A | |
| SCHEMBL16658956 | 0.89 | RAMP1 (0.40) | CALCRLRAMP1CCKBRKMT2AL3MBTL1 | |
| SCHEMBL3699627 | 0.89 | CALCRL (0.53) | CALCRLRAMP1CCKBR | |
| SCHEMBL16653123 | 0.89 | CALCRL (0.53) | CALCRLRAMP1CCKBR | |
| SCHEMBL20664219 | 0.88 | RAMP1 (0.48) | CALCRLRAMP1SCN9AKMT2AL3MBTL1 | |
| SCHEMBL30683667 | 0.88 | RAMP1 (0.48) | CALCRLRAMP1SCN9AKMT2AL3MBTL1 | |
| SCHEMBL20664272 | 0.88 | RAMP1 (0.48) | CALCRLRAMP1SCN9AKMT2AL3MBTL1 | |
| SCHEMBL15280640 | 0.88 | RAMP1 (0.48) | CALCRLRAMP1SCN9AKMT2AL3MBTL1 | |
| SCHEMBL20664225 | 0.82 | CALCRL (0.50) | CALCRLRAMP1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850246-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-12-26 | — | — | US | disclosed |
| US-9487523-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-11-08 | — | — | US | disclosed |
| US-20160130273-A1 | Process for Making CGRP Receptor Antagonists | MERCK SHARP & DOHME CORP. (US) | 2016-05-12 | — | — | US | disclosed |
| US-9174989-B2 | Process for making CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20150112067-A1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2015-04-23 | — | — | US | disclosed |
| WO-2013138418-A2 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2013-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150112067-A1 | PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS | CCKBR, BDKRB2, CALCR | CALCRL 7/4885RAMP1 19/4885SCN9A 174/4885 |
| US-20160130273-A1 | Process for Making CGRP Receptor Antagonists | CALCR, CALCRL, VIPR1 | CALCRL 2/4885RAMP1 6/4885SCN9A 566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.