Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | GRK6 | P43250 | 2/20 | 0.52 |
| ▸ | MPI | P34949 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28075492 | 0.77 | KDM4E (0.62) | KDM4EPOLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL17279690 | 0.75 | NR1H2 (0.60) | KDM4EPOLBTSHRALDH1A1HPGD | |
| SCHEMBL17280055 | 0.75 | KDM4E (0.60) | KDM4EPOLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL28075488 | 0.74 | KDM4E (0.58) | KDM4EPOLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL19356067 | 0.73 | KDM4E (0.58) | KDM4EPOLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL6741816 | 0.73 | KDM4E (0.58) | KDM4EPOLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL28075481 | 0.73 | KDM4E (0.57) | KDM4EPOLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL28095619 | 0.73 | KDM4E (0.57) | KDM4EPOLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL28833548 | 0.73 | KDM4E (0.57) | KDM4EPOLBTSHRHSD17B10ALDH1A1 | |
| SCHEMBL5789379 | 0.72 | KDM4E (1.00) | KDM4EPOLBTSHRHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948614-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2008-07-30 | — | — | EP | claimed |
| US-20070197532-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2007-08-23 | — | — | US | claimed |
| WO-2007061923-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2007-05-31 | — | — | WO | claimed |
| US-20110070297-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110070297-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| EP-1948614-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20070197532-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197532-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2007-08-23 | — | — | US | disclosed |
| US-20070197532-A1 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. | 2007-08-23 | — | — | US | disclosed |
| WO-2007061923-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007061923-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197532-A1 | GLUCOKINASE ACTIVATORS | GCK, GCKR, GALK1 | KDM4E 2963/4885POLB 2179/4885TSHR 3425/4885 |
| US-20110070297-A1 | GLUCOKINASE ACTIVATORS | GCK, GCKR, GALK1 | KDM4E 2963/4885POLB 2179/4885TSHR 3425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.