Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.57 |
| ▸ | GRK6 | P43250 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28075488 | 0.87 | KDM4E (0.58) | KDM4EPOLBTSHRGRK6FYN | |
| SCHEMBL28096008 | 0.86 | KDM4E (0.55) | KDM4EPOLBTSHRPSEN1PSEN2 | |
| SCHEMBL28095606 | 0.86 | KDM4E (0.55) | KDM4EPOLBTSHRPSEN1PSEN2 | |
| SCHEMBL28095619 | 0.86 | KDM4E (0.57) | KDM4EPOLBTSHRPSEN1PSEN2 | |
| SCHEMBL17279690 | 0.86 | NR1H2 (0.60) | KDM4EPOLBTSHRGRK6ALDH1A1 | |
| SCHEMBL28096011 | 0.84 | KDM4E (0.55) | KDM4EPOLBTSHRPSEN1PSEN2 | |
| SCHEMBL15026741 | 0.83 | PSEN1 (0.63) | KDM4EPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17280055 | 0.83 | KDM4E (0.60) | KDM4EPOLBTSHRPSEN1PSEN2 | |
| SCHEMBL28075481 | 0.83 | KDM4E (0.57) | KDM4EPOLBTSHRPSEN1PSEN2 | |
| SCHEMBL28096010 | 0.81 | KDM4E (0.55) | KDM4EPOLBTSHRGRK6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106243130-B | 3,6- diaryl-[1,2,4] triazole simultaneously [3,4-b] [1,3,4] diazthines compound and application thereof | 沈阳药科大学 | 2019-03-01 | — | — | CN | claimed |
| CN-106243130-A | 3,6 diaryl [1,2,4] triazole also [3,4 b] [1,3,4] diazthines compound and application thereof | 沈阳药科大学 | 2016-12-21 | — | — | CN | claimed |
| CN-106243130-B | 3,6- diaryl-[1,2,4] triazole simultaneously [3,4-b] [1,3,4] diazthines compound and application thereof | 沈阳药科大学 | 2019-03-01 | — | — | CN | disclosed |
| CN-106243130-A | 3,6 diaryl [1,2,4] triazole also [3,4 b] [1,3,4] diazthines compound and application thereof | 沈阳药科大学 | 2016-12-21 | — | — | CN | disclosed |