SCHEMBL15304530

SCHEMBL15304530

Cc1nc(Cl)c2oc3ccccc3c2n1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.62
MEN1 O00255 4/20 0.62
ALDH1A1 P00352 4/20 0.62
SMN1; SMN2 Q16637 3/20 0.62
CYP1A2 P05177 1/20 0.62
CYP2C19 P33261 1/20 0.62
LMNA P02545 6/20 0.58
TP53 P04637 2/20 0.58
HTT P42858 1/20 0.58
RXFP1 Q9HBX9 1/20 0.58
MAPT P10636 5/20 0.58
POLB P06746 2/20 0.58
KDM4E B2RXH2 4/20 0.57
HPGD P15428 2/20 0.57
HSD17B10 Q99714 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
MAPK1 P28482 2/20 0.56
HRH4 Q9H3N8 1/20 0.56
USP2 O75604 1/20 0.56
TSHR P16473 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29850525 1.00 KMT2A (0.62) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL1310612 0.84 SMN1; SMN2 (0.62) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL22193759 0.84 LMNA (0.61) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL31673315 0.82 SMN1; SMN2 (0.55) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL24846182 0.82 KMT2A (0.52) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL4593418 0.82 KMT2A (0.66) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL20668101 0.81 MAPK1 (0.66) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL31673332 0.81 MAPK1 (0.66) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL31673100 0.81 SMN1; SMN2 (0.54) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL6857798 0.81 SMN1; SMN2 (0.50) KMT2AMEN1ALDH1A1SMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250257076-A1 SUBSTITUTED PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS cGAS INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2025-08-14 US disclosed
US-20240174684-A1 INHIBITORS OF cGAS ACTIVITY AS THERAPEUTIC AGENTS BELLBROOK LABS, LLC 2024-05-30 US disclosed
WO-2024035622-A1 INHIBITORS OF cGAS ACTIVITY AS THERAPEUTIC AGENTS BELLBROOK LABS, LLC (US) 2024-02-15 WO disclosed
WO-2024035622-A1 INHIBITORS OF cGAS ACTIVITY AS THERAPEUTIC AGENTS BELLBROOK LABS, LLC (US) 2024-02-15 WO disclosed
EP-4291188-A1 INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS Bellbrook Labs, Llc (US) 2023-12-20 EP disclosed
CN-116997339-A Inhibitors of cGAS activity as therapeutic agents 贝尔布鲁克实验室有限责任公司 2023-11-03 CN disclosed
US-20230000878-A1 PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2023-01-05 US disclosed
US-20220117968-A1 THIENO[2,3-D)PYRIMIDINES AND BENZOFURO(3,2-D)PYRIMIDINES AS ANTIMICROBIAL AGENTS SAINT LOUIS UNIVERSITY 2022-04-21 US disclosed
US-20220117968-A1 THIENO[2,3-D)PYRIMIDINES AND BENZOFURO(3,2-D)PYRIMIDINES AS ANTIMICROBIAL AGENTS SAINT LOUIS UNIVERSITY 2022-04-21 US disclosed
US-20220073532-A1 INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS BELLBROOK LABS, LLC 2022-03-10 US disclosed
EP-3906241-A1 INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS Bellbrook Labs, Llc (US) 2021-11-10 EP disclosed
CN-113302194-A Inhibitors of cGAS activity as therapeutic agents 贝尔布鲁克实验室有限责任公司 2021-08-24 CN disclosed
WO-2020142729-A1 INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS BellBrook Labs (US) 2020-07-09 WO disclosed
EP-3565810-A1 PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION ViiV Healthcare UK (No.5) Limited (GB) 2019-11-13 EP disclosed
WO-2019018359-A1 THIENO[2,3-D)PYRIMIDINES AND BENZOFURO(3,2-D)PYRIMIDINES AS ANTIMICROBIAL AGENTS SAINT LOUIS UNIVERSITY (US) 2019-01-24 WO disclosed
WO-2019018359-A1 THIENO[2,3-D)PYRIMIDINES AND BENZOFURO(3,2-D)PYRIMIDINES AS ANTIMICROBIAL AGENTS SAINT LOUIS UNIVERSITY (US) 2019-01-24 WO disclosed
WO-2018127801-A1 PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION VIIV Healthcare UK (No.5) Limited (GB) 2018-07-12 WO disclosed
US-8552018-B2 Substituted tricyclic compounds as protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2013-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240174684-A1 INHIBITORS OF cGAS ACTIVITY AS THERAPEUTIC AGENTS CGAS, STING1, IRF3 KMT2A 3981/4885MEN1 3914/4885ALDH1A1 4232/4885
US-20220117968-A1 THIENO[2,3-D)PYRIMIDINES AND BENZOFURO(3,2-D)PYRIMIDINES AS ANTIMICROBIAL AGENTS TYMS, DPYD, UMPS KMT2A 3758/4885MEN1 4593/4885ALDH1A1 924/4885
US-20250257076-A1 SUBSTITUTED PYRROLIDINE-2-CARBOXYLIC ACID DERIVATIVES AS cGAS INHIBITORS CGAS, SSB, FPGS KMT2A 2247/4885MEN1 2128/4885ALDH1A1 1529/4885
US-20220073532-A1 INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENTS CGAS, STING1, IRF3 KMT2A 3981/4885MEN1 3914/4885ALDH1A1 4232/4885
US-20230000878-A1 PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS CGAS, GLS2, GMPS KMT2A 4804/4885MEN1 2956/4885ALDH1A1 1112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.