Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.64 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2044064 | 0.75 | HSD11B1 (1.00) | EPHX2HSD11B1L3MBTL1 | |
| SCHEMBL3855440 | 0.72 | HSD11B1 (0.61) | EPHX2HSD11B1L3MBTL1 | |
| SCHEMBL10154838 | 0.70 | CYP2D6 (0.43) | EPHX2HSD11B1EPHX1 | |
| SCHEMBL19798424 | 0.69 | KMT2A (0.58) | EPHX2HSD11B1L3MBTL1HSD17B10EPHX1 | |
| SCHEMBL10121240 | 0.67 | EPHX2 (0.41) | EPHX2HSD11B1EPHX1 | |
| SCHEMBL1402900 | 0.67 | L3MBTL1 (0.59) | EPHX2HSD11B1L3MBTL1HSD17B10EPHX1 | |
| SCHEMBL14159611 | 0.67 | HSD11B1 (0.73) | EPHX2HSD11B1EPHX1 | |
| SCHEMBL1402948 | 0.66 | HSD11B1 (0.59) | EPHX2HSD11B1L3MBTL1HSD17B10EPHX1 | |
| SCHEMBL22941133 | 0.66 | CYP2D6 (0.46) | EPHX2EPHX1KMT2A | |
| SCHEMBL12968364 | 0.66 | L3MBTL1 (0.72) | EPHX2HSD11B1L3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094263-B1 | 2-ADAMANTYL-BUTYRAMIDE DERIVATIVES AS SELECTIVE 11 BETA-HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2013-10-16 | — | — | EP | claimed |