Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 6/20 | 0.47 |
| ▸ | GSK3B | P49841 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP9 | P55211 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | IL33 | O95760 | 2/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15312858 | 1.00 | CDK2 (0.61) | CDK2INSRIGF1RGSK3AGSK3B | |
| SCHEMBL623099 | 0.82 | IL33 (0.43) | CDK2INSRIGF1RGSK3AGSK3B | |
| SCHEMBL10118538 | 0.80 | CDK2 (0.49) | CDK2INSRIGF1RGSK3AGSK3B | |
| SCHEMBL10118581 | 0.77 | IL33 (0.44) | CDK2INSRIGF1RKMT2AKDM4E | |
| SCHEMBL623595 | 0.77 | MAPK1 (0.49) | KMT2AKDM4EPKMNPSR1IL33 | |
| SCHEMBL626664 | 0.76 | CDK2 (1.00) | CDK2INSRIGF1RGSK3AGSK3B | |
| SCHEMBL12505114 | 0.76 | CDK2 (1.00) | CDK2INSRIGF1RGSK3AGSK3B | |
| SCHEMBL626665 | 0.76 | CDK2 (1.00) | CDK2INSRIGF1RGSK3AGSK3B | |
| SCHEMBL30509894 | 0.76 | CDK2 (1.00) | CDK2INSRIGF1RGSK3AGSK3B | |
| SCHEMBL15315401 | 0.75 | IL33 (0.49) | KMT2AKDM4EPKMNPSR1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255088-B2 | Premature-termination-codons readthrough compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-09 | — | — | US | disclosed |
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | UPF1, NUDT21, RNGTT | CDK2 960/4885INSR 4125/4885IGF1R 4789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.