Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | BCL2 | P10415 | 4/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | RIOK2 | Q9BVS4 | 3/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.41 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313672 | 0.73 | SOX18 (0.47) | ALOX5BCL2MCL1CES2HTR2A | |
| SCHEMBL15313972 | 0.73 | BCL2 (0.75) | BCL2MCL1L3MBTL1MEN1KMT2A | |
| SCHEMBL15314352 | 0.73 | BCL2 (0.54) | BCL2MCL1MEN1KMT2AGABRA1 | |
| 2-Naphthylacetic Acid SCHEMBL11542553 | 0.71 | NR1H4 (0.63) | ALOX5L3MBTL1NR1H4HTR2AHTR2C | |
| SCHEMBL10137777 | 0.71 | CYP1A2 (0.53) | ALOX5NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL1167938 | 0.71 | MAPT (0.66) | ALOX5MEN1KMT2ACYP1A2CYP2A6 | |
| SCHEMBL18326334 | 0.70 | ALOX5 (0.56) | ALOX5MEN1KMT2ARIOK2GSK3A | |
| SCHEMBL31204539 | 0.70 | HTR2C (0.50) | ALOX5NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL9129189 | 0.70 | HTR2A (0.46) | ALOX5L3MBTL1MEN1KMT2ANR1H4 | |
| SCHEMBL9711266 | 0.70 | PTPN1 (0.62) | ALOX5MEN1KMT2ANR1H4CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |