Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOX18 | P35713 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313673 | 0.73 | ALOX5 (0.56) | CES2HTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL6240981 | 0.73 | CYP1A2 (0.65) | SOX18HTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL29560700 | 0.73 | CYP1A2 (0.65) | SOX18HTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL15313711 | 0.71 | BCL2 (0.59) | BCL2MCL1 | |
| SCHEMBL20332772 | 0.71 | SOX18 (0.53) | SOX18CYP1A2CYP2A6SIGMAR1ALOX5 | |
| SCHEMBL21517641 | 0.70 | ESR1 (0.58) | SOX18CYP1A2CYP2A6SIGMAR1ALOX5 | |
| SCHEMBL26745727 | 0.70 | SOX18 (0.63) | SOX18HTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL2482277 | 0.69 | HTR2A (0.53) | SOX18CES2HTR2AHTR2CHTR2B | |
| SCHEMBL18269436 | 0.69 | CYP1A2 (0.57) | SOX18CES2HTR2AHTR2CHTR2B | |
| SCHEMBL26745958 | 0.69 | SOX18 (0.51) | SOX18HTR2AHTR2CHTR2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |