Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 10/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4162844 | 0.90 | TYR (0.49) | TYRALOX5CYP3A4MEN1TP53 | |
| SCHEMBL15313674 | 0.80 | PTGS2 (0.47) | TYRALOX5CYP3A4MEN1TP53 | |
| SCHEMBL15313669 | 0.80 | PTGS2 (0.47) | TYRALOX5CYP3A4MEN1TP53 | |
| SCHEMBL15313670 | 0.80 | PTGS2 (0.47) | TYRALOX5CYP3A4MEN1TP53 | |
| SCHEMBL31544904 | 0.78 | TYR (0.61) | TYRALOX5CYP3A4MEN1TP53 | |
| SCHEMBL11805847 | 0.77 | ALOX5 (0.45) | TYRALOX5CYP3A4MEN1TP53 | |
| SCHEMBL5517885 | 0.76 | TYR (0.59) | TYRALOX5CYP3A4MEN1TP53 | |
| SCHEMBL11504879 | 0.74 | TRPV1 (0.42) | TYRALOX5ALOX15HTTTRPV1 | |
| SCHEMBL4162845 | 0.74 | TYR (0.45) | TYRALOX5CYP3A4MEN1TP53 | |
| SCHEMBL5680552 | 0.74 | TYR (0.51) | TYRALOX5CYP3A4MEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |