Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.47 |
| ▸ | TYR | P14679 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313669 | 1.00 | PTGS2 (0.47) | PTGS2ALOX5TYRCYP3A4MEN1 | |
| SCHEMBL15313674 | 1.00 | PTGS2 (0.47) | PTGS2ALOX5TYRCYP3A4MEN1 | |
| SCHEMBL4162844 | 0.87 | TYR (0.49) | PTGS2ALOX5TYRCYP3A4MEN1 | |
| SCHEMBL11805847 | 0.83 | ALOX5 (0.45) | PTGS2ALOX5TYRCYP3A4MEN1 | |
| SCHEMBL4162846 | 0.83 | TYR (0.56) | PTGS2ALOX5TYRCYP3A4MEN1 | |
| SCHEMBL10899469 | 0.81 | PTGS2 (0.43) | PTGS2ALOX5TYRCYP3A4MEN1 | |
| SCHEMBL10894690 | 0.81 | PTGS2 (0.43) | PTGS2ALOX5TYRCYP3A4MEN1 | |
| SCHEMBL10894779 | 0.81 | PTGS2 (0.43) | PTGS2ALOX5TYRCYP3A4MEN1 | |
| SCHEMBL15313676 | 0.80 | TYR (0.49) | PTGS2ALOX5TYRCYP3A4MEN1 | |
| SCHEMBL5588983 | 0.79 | MAPK1 (0.42) | PTGS2ALOX5TYRCYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |