Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7775778 | 0.87 | PLA2G2A (0.53) | HTTFFAR1PLA2G2APLA2G5CES2 | |
| SCHEMBL7773832 | 0.87 | PLA2G2A (0.53) | HTTFFAR1PLA2G2APLA2G5CES2 | |
| SCHEMBL7773963 | 0.87 | PLA2G2A (0.53) | HTTFFAR1PLA2G2APLA2G5CES2 | |
| SCHEMBL9468226 | 0.87 | PLA2G2A (0.53) | HTTFFAR1PLA2G2APLA2G5CES2 | |
| SCHEMBL9636706 | 0.86 | HTT (0.43) | BCL2HTTFFAR1PLA2G2APLA2G5 | |
| SCHEMBL7773975 | 0.86 | HTT (0.51) | HTTFFAR1PLA2G2APLA2G5MEN1 | |
| SCHEMBL15314345 | 0.83 | BCL2 (0.61) | BCL2PTPN1PTPN2PTPN6 | |
| SCHEMBL15313677 | 0.77 | CNR1 (0.48) | BCL2HTTMEN1MAPTKMT2A | |
| SCHEMBL28707306 | 0.77 | PTPN1 (0.73) | BCL2PTPN1PTPN2PTPN6 | |
| SCHEMBL10360259 | 0.75 | THRA (0.46) | HTTEPHX2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |