Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.40 |
| ▸ | TYR | P14679 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | BID | P55957 | 2/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15314353 | 0.78 | PPARG (0.42) | CYSLTR2CYSLTR1MEN1TP53KMT2A | |
| SCHEMBL15313680 | 0.77 | FFAR1 (0.45) | CYSLTR2CYSLTR1ALOX5MEN1MAPT | |
| SCHEMBL15313669 | 0.76 | PTGS2 (0.47) | HTR2ALIPGALOX5TYRMEN1 | |
| SCHEMBL15313670 | 0.76 | PTGS2 (0.47) | HTR2ALIPGALOX5TYRMEN1 | |
| SCHEMBL15313674 | 0.76 | PTGS2 (0.47) | HTR2ALIPGALOX5TYRMEN1 | |
| SCHEMBL28035909 | 0.75 | TSHR (0.46) | HTR2AMEN1TP53ALOX15TSHR | |
| SCHEMBL1837403 | 0.75 | TSHR (0.46) | HTR2AMEN1TP53ALOX15TSHR | |
| SCHEMBL1833046 | 0.75 | TSHR (0.46) | HTR2AMEN1TP53ALOX15TSHR | |
| SCHEMBL28036382 | 0.75 | TSHR (0.46) | HTR2AMEN1TP53ALOX15TSHR | |
| SCHEMBL1835642 | 0.75 | TSHR (0.46) | HTR2AMEN1TP53ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |