Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.45 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.41 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15314353 | 0.91 | PPARG (0.42) | ALDH1A1MEN1KMT2ACYSLTR2CYSLTR1 | |
| SCHEMBL9468232 | 0.80 | PLA2G2A (0.55) | FFAR1PLA2G2APLA2G5HTTALDH1A1 | |
| SCHEMBL15313675 | 0.79 | PLA2G2A (0.54) | FFAR1PLA2G2APLA2G5HTTALDH1A1 | |
| SCHEMBL6654044 | 0.79 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2AASAH1ACER2 | |
| SCHEMBL15313671 | 0.79 | PLA2G2A (0.54) | FFAR1PLA2G2APLA2G5HTTALDH1A1 | |
| SCHEMBL15313668 | 0.77 | PLA2G2A (0.51) | FFAR1PLA2G2APLA2G5HTTALDH1A1 | |
| SCHEMBL15313679 | 0.77 | CYSLTR2 (0.46) | ALOX5HTTMEN1MAPTKMT2A | |
| SCHEMBL28441962 | 0.76 | ALDH1A1 (0.51) | ALDH1A1 | |
| SCHEMBL31108377 | 0.74 | ASAH1 (0.52) | ALDH1A1MAPTKMT2AASAH1ACER2 | |
| SCHEMBL7011219 | 0.74 | ASAH1 (0.52) | ALDH1A1MAPTKMT2AASAH1ACER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |