Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313768 | 0.84 | BCL2 (0.44) | CYP3A4CYP2C19 | |
| SCHEMBL3821734 | 0.82 | BCL2 (0.43) | IGF1RALOX15 | |
| SCHEMBL15313688 | 0.80 | IGF1R (0.43) | TDP1L3MBTL1ATMIGF1RALOX15 | |
| SCHEMBL3815076 | 0.78 | IGF1R (0.45) | IGF1RALOX15 | |
| SCHEMBL28678789 | 0.77 | TYR (0.42) | BACE1ALDH1A1 | |
| SCHEMBL3819520 | 0.76 | RARB (0.46) | CNR1ALDH1A1CYP3A4 | |
| SCHEMBL15314346 | 0.76 | RARB (0.46) | CNR1ALDH1A1CYP3A4 | |
| SCHEMBL15313773 | 0.75 | TSHR (0.41) | FFAR1FFAR4IGF1RALOX15CNR1 | |
| P-Xylene SCHEMBL20836571 | 0.74 | HTR2A (0.56) | TDP1L3MBTL1ATMALDH1A1CYP1A2 | |
| SCHEMBL28700316 | 0.73 | BACE1 (0.42) | BACE1ALDH1A1LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |