Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | BCL2 | P10415 | 2/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821734 | 0.95 | BCL2 (0.43) | IGF1RALOX15BCL2BCL2L1PTPN1 | |
| SCHEMBL3819520 | 0.93 | RARB (0.46) | MAPT | |
| SCHEMBL15314346 | 0.93 | RARB (0.46) | MAPT | |
| SCHEMBL15313782 | 0.89 | PTPN1 (0.50) | BCL2BCL2L1PTPN1PTPN2PTPN6 | |
| SCHEMBL15313768 | 0.82 | BCL2 (0.44) | BCL2BCL2L1PTPN1PTPN2PTPN6 | |
| SCHEMBL15313779 | 0.79 | ESR1 (0.42) | MAPT | |
| SCHEMBL15313769 | 0.78 | BCL2 (0.41) | BCL2BCL2L1PTPN1PTPN2PTPN6 | |
| SCHEMBL15313772 | 0.78 | TDP1 (0.46) | IGF1RALOX15 | |
| SCHEMBL15313695 | 0.77 | PTPN1 (0.58) | ALOX15BCL2BCL2L1PTPN1PTPN2 | |
| SCHEMBL15313896 | 0.77 | BCL2 (0.59) | BCL2BCL2L1PTPN1PTPN2PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| EP-1778206-A4 | SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF | UNIV MICHIGAN (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1778206-A2 | SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006023778-A2 | SMALL MOLECULE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-03-02 | — | — | WO | disclosed |