Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 4/20 | 0.36 |
| ▸ | ESRRB | O95718 | 3/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313775 | 0.88 | TSHR (0.42) | TSHRBACE1MAPTNPC1RAB9A | |
| SCHEMBL15313769 | 0.75 | BCL2 (0.41) | NPC1RAB9ALMNA | |
| SCHEMBL15313772 | 0.75 | TDP1 (0.46) | BACE1IGF1RALOX15FFAR1FFAR4 | |
| SCHEMBL15313768 | 0.70 | BCL2 (0.44) | TSHR | |
| SCHEMBL14702258 | 0.69 | CYP2C19 (0.39) | TSHRBACE1MAPTNPC1RAB9A | |
| SCHEMBL7456580 | 0.68 | KCNH2 (0.59) | TSHRGPR84ESRRGESRRBDAO | |
| SCHEMBL12032216 | 0.67 | RXRA (0.49) | GPR84RXRARXRBRXRGESRRG | |
| SCHEMBL22346252 | 0.66 | TSHR (0.50) | TSHRBACE1MAPTNPC1RAB9A | |
| SCHEMBL28831154 | 0.66 | ALDH1A1 (0.53) | TSHRBACE1MAPTNPC1RAB9A | |
| SCHEMBL10357135 | 0.66 | PTGS1 (0.53) | GPR84MAPTDAOIGF1RALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |