Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 2/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.40 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.40 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.40 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313687 | 0.83 | SIGMAR1 (0.43) | IGF1RALOX15BCL2BCL2L1 | |
| SCHEMBL15313716 | 0.82 | FFAR1 (0.44) | IGF1RALOX15BCL2BCL2L1PLAAT3 | |
| SCHEMBL15313772 | 0.80 | TDP1 (0.46) | IGF1RALOX15TDP1L3MBTL1PLAAT3 | |
| SCHEMBL11826291 | 0.80 | PTPN1 (0.58) | PTPN1PTPN2PTPN6BCL2BCL2L1 | |
| SCHEMBL15313677 | 0.78 | CNR1 (0.48) | ALOX15BCL2BCL2L1TDP1 | |
| SCHEMBL3821734 | 0.77 | BCL2 (0.43) | IGF1RALOX15PTPN1PTPN2PTPN6 | |
| SCHEMBL8930618 | 0.76 | BCL2 (0.61) | ALOX15PTPN1PTPN2PTPN6BCL2 | |
| SCHEMBL2356590 | 0.76 | HTR2A (0.60) | TDP1L3MBTL1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL15313690 | 0.75 | BCL2 (0.43) | ALOX15PTPN1PTPN2PTPN6BCL2 | |
| SCHEMBL15313768 | 0.75 | BCL2 (0.44) | PTPN1PTPN2PTPN6BCL2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |