Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.75 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.75 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.75 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.75 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.37 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313806 | 0.87 | BCL2L1 (0.59) | BCL2BCL2L1MCL1SIRT5RORC | |
| SCHEMBL29359532 | 0.86 | BCL2 (1.00) | BCL2BCL2L1MCL1SIRT5HSD11B1 | |
| SCHEMBL687266 | 0.86 | BCL2 (1.00) | BCL2BCL2L1MCL1SIRT5HSD11B1 | |
| SCHEMBL29360605 | 0.86 | BCL2 (1.00) | BCL2BCL2L1MCL1SIRT5HSD11B1 | |
| SCHEMBL15313794 | 0.84 | BCL2L1 (0.56) | BCL2BCL2L1MCL1SIRT5RORC | |
| SCHEMBL15313797 | 0.82 | BCL2L1 (0.54) | BCL2BCL2L1MCL1SIRT5RORC | |
| SCHEMBL20153703 | 0.81 | BCL2 (0.84) | BCL2BCL2L1MCL1SIRT5AVPR2 | |
| SCHEMBL15313829 | 0.80 | BCL2 (0.80) | BCL2BCL2L1MCL1SIRT5PTPRC | |
| SCHEMBL15313821 | 0.80 | BCL2 (0.79) | BCL2BCL2L1MCL1SIRT5KCNK3 | |
| SCHEMBL22781207 | 0.79 | BCL2 (0.87) | BCL2BCL2L1MCL1SIRT5HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |