Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.56 |
| ▸ | BCL2 | P10415 | 4/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.51 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.41 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313797 | 0.96 | BCL2L1 (0.54) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313806 | 0.88 | BCL2L1 (0.59) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313804 | 0.86 | BCL2L1 (0.72) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313802 | 0.84 | BCL2 (0.75) | BCL2L1BCL2MCL1SIRT5AVPR2 | |
| SCHEMBL15313787 | 0.82 | BCL2 (0.56) | BCL2L1BCL2MCL1SIRT5PPARG | |
| SCHEMBL15313807 | 0.78 | BCL2L1 (0.79) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313895 | 0.77 | BCL2L1 (0.84) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313786 | 0.76 | BCL2 (0.67) | BCL2L1BCL2MCL1SIRT5KDM4E | |
| SCHEMBL15313791 | 0.73 | LMNA (0.57) | NR1H4ESRRGLMNA | |
| SCHEMBL15313789 | 0.71 | BCL2 (0.57) | BCL2L1BCL2MCL1SIRT5PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |