Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.59 |
| ▸ | BCL2 | P10415 | 4/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.54 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | KLK1 | P06870 | 2/20 | 0.39 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313797 | 0.92 | BCL2L1 (0.54) | BCL2L1BCL2MCL1SIRT5PLG | |
| SCHEMBL15313794 | 0.88 | BCL2L1 (0.56) | BCL2L1BCL2MCL1SIRT5ESRRG | |
| SCHEMBL15313802 | 0.87 | BCL2 (0.75) | BCL2L1BCL2MCL1SIRT5RORC | |
| SCHEMBL15313807 | 0.86 | BCL2L1 (0.79) | BCL2L1BCL2MCL1SIRT5PLG | |
| SCHEMBL15313895 | 0.79 | BCL2L1 (0.84) | BCL2L1BCL2MCL1SIRT5NR1H4 | |
| SCHEMBL15313804 | 0.78 | BCL2L1 (0.72) | BCL2L1BCL2MCL1SIRT5PLG | |
| SCHEMBL15313856 | 0.76 | BCL2L1 (0.77) | BCL2L1BCL2MCL1SIRT5PLG | |
| SCHEMBL15313805 | 0.74 | BCL2 (0.58) | BCL2L1BCL2MCL1SIRT5NR1H4 | |
| SCHEMBL15313820 | 0.73 | BCL2 (1.00) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313787 | 0.72 | BCL2 (0.56) | BCL2L1BCL2MCL1SIRT5PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |