Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 8/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.58 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.58 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.36 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313814 | 0.87 | BCL2 (0.68) | BCL2MCL1BCL2L1SIRT5GAA | |
| SCHEMBL15005278 | 0.85 | BCL2 (0.51) | BCL2MCL1BCL2L1SIRT5LPAR1 | |
| SCHEMBL15313828 | 0.83 | BCL2 (0.55) | BCL2MCL1BCL2L1SIRT5LMNA | |
| SCHEMBL15313891 | 0.80 | ALDH1A1 (0.49) | BCL2MCL1BCL2L1SIRT5GAA | |
| SCHEMBL15313849 | 0.78 | BCL2 (0.67) | BCL2MCL1BCL2L1SIRT5GAA | |
| SCHEMBL15313887 | 0.78 | BCL2 (0.56) | BCL2MCL1BCL2L1SIRT5LMNA | |
| SCHEMBL15313842 | 0.77 | BCL2 (0.68) | BCL2MCL1BCL2L1SIRT5LMNA | |
| SCHEMBL15554034 | 0.76 | BCL2 (0.77) | BCL2MCL1BCL2L1SIRT5GAA | |
| SCHEMBL687266 | 0.75 | BCL2 (1.00) | BCL2MCL1BCL2L1SIRT5LMNA | |
| SCHEMBL15313801 | 0.75 | BCL2L1 (0.60) | BCL2MCL1BCL2L1SIRT5GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |