Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313899 | 0.84 | BCL2 (0.67) | BCL2BCL2L1MAOAKMT2AALDH1A1 | |
| SCHEMBL15313814 | 0.82 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5KMT2A | |
| SCHEMBL15313816 | 0.78 | BCL2 (0.58) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313849 | 0.76 | BCL2 (0.67) | BCL2BCL2L1MCL1SIRT5ALDH1A1 | |
| SCHEMBL15313828 | 0.74 | BCL2 (0.55) | BCL2BCL2L1MCL1SIRT5ALDH1A1 | |
| SCHEMBL15313842 | 0.74 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5KMT2A | |
| SCHEMBL15313898 | 0.73 | MAOA (0.46) | MAOAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL15313823 | 0.72 | BCL2 (0.72) | BCL2BCL2L1MCL1SIRT5MAPT | |
| SCHEMBL687266 | 0.72 | BCL2 (1.00) | BCL2BCL2L1MCL1SIRT5ALDH1A1 | |
| SCHEMBL29359532 | 0.72 | BCL2 (1.00) | BCL2BCL2L1MCL1SIRT5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |