Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430743 | 0.81 | HSPA5 (0.54) | HSPA5 | |
| SCHEMBL28261836 | 0.81 | GABRA1 (0.48) | GABRA1GABRB2TSHRGABRG2GABRB3 | |
| SCHEMBL21734367 | 0.77 | GABRA1 (0.67) | GABRA1GABRB2TSHRGABRG2GABRB3 | |
| SCHEMBL35864 | 0.77 | HSPA5 (0.43) | HIF1ALMNACYP3A4HPGDBLM | |
| SCHEMBL29368767 | 0.77 | HSPA5 (0.43) | HIF1ALMNACYP3A4HPGDBLM | |
| SCHEMBL128057 | 0.74 | HMGB1 (0.50) | GABRA1GABRB2TSHRGABRG2GABRB3 | |
| SCHEMBL6546915 | 0.72 | TAAR1 (0.42) | GABRA1GABRB2TSHRGABRG2GABRB3 | |
| Hydrogen Peroxide SCHEMBL29140083 | 0.72 | L3MBTL1 (0.50) | GABRA1GABRB2TSHRGABRG2GABRB3 | |
| SCHEMBL10397566 | 0.71 | GABRA1 (0.41) | GABRA1GABRB2TSHRGABRG2GABRB3 | |
| SCHEMBL10871287 | 0.70 | GABRA1 (0.55) | GABRA1GABRB2TSHRGABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |