Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 6/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 2/20 | 0.53 |
| ▸ | PTPN13 | Q12923 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 5/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313875 | 0.81 | MAOA (0.47) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL15313864 | 0.74 | BCL2L1 (0.65) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL29790411 | 0.73 | ACE2 (0.68) | PTPRCCTSLPTPN1CTSSPTPN13 | |
| SCHEMBL15490695 | 0.73 | ACE2 (0.68) | PTPRCCTSLPTPN1CTSSPTPN13 | |
| SCHEMBL29790438 | 0.72 | ACE2 (0.70) | PTPRCCTSLPTPN1CTSSPTPN13 | |
| SCHEMBL15490693 | 0.72 | ACE2 (0.70) | PTPRCCTSLPTPN1CTSSPTPN13 | |
| SCHEMBL24634803 | 0.71 | ACE2 (0.78) | PTPRCCTSLPTPN1CTSSPTPN13 | |
| SCHEMBL5491008 | 0.71 | DEGS1 (0.60) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL9311893 | 0.71 | MEN1 (0.71) | PTPRCCTSLPTPN1CTSSPTPN13 | |
| SCHEMBL30519331 | 0.70 | ACE2 (1.00) | PTPRCCTSLPTPN1CTSSPTPN13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |