Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | KLK1 | P06870 | 2/20 | 0.44 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | STK39 | Q9UEW8 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313898 | 0.84 | MAOA (0.46) | MAOAKMT2AMEN1MAPTLMNA | |
| SCHEMBL13576567 | 0.82 | MEN1 (0.63) | MAOAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL15313885 | 0.81 | MAOA (0.44) | MAOAKMT2AMEN1MAPTLMNA | |
| SCHEMBL15313879 | 0.81 | PTPRC (0.53) | MAOAKMT2AMEN1MAPTLMNA | |
| SCHEMBL15313899 | 0.76 | BCL2 (0.67) | MAOAKMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL15313887 | 0.72 | BCL2 (0.56) | MAOAKMT2AMEN1MAPTLMNA | |
| SCHEMBL11304698 | 0.70 | MEN1 (0.55) | KMT2AMEN1MAPTLMNANPC1 | |
| SCHEMBL15313864 | 0.69 | BCL2L1 (0.65) | KMT2AMEN1MAPTLMNANPC1 | |
| SCHEMBL4869345 | 0.69 | CA12 (0.68) | MAOAKMT2AMEN1MAPTNPC1 | |
| SCHEMBL5491008 | 0.68 | DEGS1 (0.60) | KMT2AMEN1MAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |