Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313884 | 0.77 | BCL2L1 (0.59) | MAPTRXFP1SMN1; SMN2POLBBLM | |
| SCHEMBL15313842 | 0.76 | BCL2 (0.68) | SMN1; SMN2LMNAHPGDALDH1A1MEN1 | |
| SCHEMBL15313835 | 0.76 | CA12 (0.51) | RXFP1SMN1; SMN2LMNAHPGDALDH1A1 | |
| SCHEMBL15313838 | 0.75 | BCL2 (0.66) | SMN1; SMN2LMNAHPGDALDH1A1MEN1 | |
| SCHEMBL30116584 | 0.74 | STING1 (0.55) | MAPTRXFP1SMN1; SMN2POLBBLM | |
| SCHEMBL15313846 | 0.73 | BCL2 (0.57) | MAPTLMNAHPGDALDH1A1MEN1 | |
| SCHEMBL3737205 | 0.72 | LMNA (0.62) | MAPTPOLBLMNATP53HPGD | |
| SCHEMBL20110420 | 0.72 | TP53 (0.60) | SMN1; SMN2TP53MEN1KMT2A | |
| SCHEMBL15313839 | 0.68 | CA12 (0.53) | MAPTSMN1; SMN2POLBLMNAHPGD | |
| SCHEMBL6032487 | 0.67 | MAPT (0.61) | MAPTSMN1; SMN2POLBLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |