Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | GPR27 | Q9NS67 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313839 | 0.89 | CA12 (0.53) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL15313842 | 0.83 | BCL2 (0.68) | CA12CA1CA2CA9GPR27 | |
| SCHEMBL15313838 | 0.82 | BCL2 (0.66) | CA12CA1CA2CA9GPR27 | |
| SCHEMBL15313834 | 0.80 | ALOX12 (0.54) | CA2GPR27KMT2AAVPR2 | |
| SCHEMBL15313846 | 0.79 | BCL2 (0.57) | GPR27KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL15313830 | 0.76 | GPR27 (0.61) | GPR27MEN1KMT2AAVPR2 | |
| SCHEMBL15313831 | 0.76 | GPR27 (0.61) | GPR27KDM4EMEN1KMT2AAVPR2 | |
| SCHEMBL15313883 | 0.76 | MAPT (0.45) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL15313911 | 0.75 | BCL2 (0.53) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL21708271 | 0.72 | L3MBTL1 (0.66) | MEN1KMT2AALDH1A1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |