Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15314639 | 0.87 | CNR1 (0.38) | DHODHALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL12761404 | 0.86 | DHODH (0.42) | DHODHALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL12833476 | 0.82 | HSD17B1 (0.44) | DHODHALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2051020 | 0.79 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HPGDHTTKDM4E | |
| SCHEMBL15314599 | 0.78 | HTR2A (0.40) | DHODHALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL18902229 | 0.77 | DHODH (0.38) | DHODHALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL15314601 | 0.77 | NQO1 (0.43) | ALDH1A1SMN1; SMN2MAPTHPGDKDM4E | |
| SCHEMBL15314653 | 0.76 | MAPT (0.47) | ALDH1A1SMN1; SMN2MAPTLMNAHPGD | |
| SCHEMBL15314602 | 0.75 | LMNA (0.33) | DHODHALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL12761437 | 0.75 | DHODH (0.39) | DHODHALDH1A1SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971595-B1 | CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-16 | — | — | EP | disclosed |