Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | VEGFA | P15692 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL272206 | 0.87 | VEGFA (0.58) | KMT2APKMCCR5KDM4EALDH1A1 | |
| SCHEMBL30402261 | 0.74 | EGLN1 (0.64) | KDM4ESMN1; SMN2LMNAVEGFAEGLN1 | |
| SCHEMBL17340661 | 0.73 | VEGFA (0.57) | L3MBTL1ALDH1A1VEGFAEGLN1 | |
| SCHEMBL23531478 | 0.73 | KMT2A (0.70) | KMT2APKMCCR5L3MBTL1ATM | |
| SCHEMBL18541807 | 0.73 | KMT2A (0.70) | KMT2APKMCCR5L3MBTL1ATM | |
| SCHEMBL28130536 | 0.73 | KMT2A (0.70) | KMT2APKMCCR5L3MBTL1ATM | |
| SCHEMBL17340697 | 0.73 | VEGFA (0.67) | KDM4EATMALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL17340673 | 0.72 | EGLN1 (0.71) | KMT2ASMN1; SMN2MEN1VEGFAEGLN1 | |
| SCHEMBL15314777 | 0.71 | CNR2 (0.42) | KDM4EALDH1A1LMNAVEGFAEGLN1 | |
| SCHEMBL17340662 | 0.71 | VEGFA (0.49) | L3MBTL1ALDH1A1SMN1; SMN2VEGFAEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2952192-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-2649998-B1 | Prolyl hydroxylase inhibitors | AERPIO THERAPEUTICS INC (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-2649998-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2013-10-16 | — | — | EP | disclosed |