Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 2/20 | 0.67 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17340661 | 0.92 | VEGFA (0.57) | VEGFAEGLN1SIGMAR1ALDH1A1 | |
| SCHEMBL17340685 | 0.85 | EGLN1 (0.50) | VEGFAEGLN1ALDH1A1 | |
| SCHEMBL17340662 | 0.84 | VEGFA (0.49) | VEGFAEGLN1ALDH1A1SMN1; SMN2DRD4 | |
| SCHEMBL278202 | 0.81 | VEGFA (1.00) | VEGFAEGLN1SIGMAR1ALDH1A1KDM4E | |
| SCHEMBL17340673 | 0.75 | EGLN1 (0.71) | VEGFAEGLN1SMN1; SMN2 | |
| SCHEMBL17340652 | 0.74 | VEGFA (0.60) | VEGFAEGLN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL15314777 | 0.74 | CNR2 (0.42) | VEGFAEGLN1ALDH1A1KDM4ELMNA | |
| SCHEMBL273037 | 0.74 | EGLN1 (0.87) | VEGFAEGLN1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL272076 | 0.74 | VEGFA (0.85) | VEGFAEGLN1MC4RALDH1A1KDM4E | |
| SCHEMBL272116 | 0.74 | VEGFA (0.85) | VEGFAEGLN1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2954899-A1 | COMPOSITIONS AND METHODS FOR TREATING COLITIS | Aerpio Therapeutics, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |