Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.71 |
| ▸ | VEGFA | P15692 | 5/20 | 0.71 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15314765 | 0.84 | EGLN1 (0.51) | EGLN1VEGFAMAPK14BRD4BRD2 | |
| SCHEMBL272200 | 0.83 | EGLN1 (1.00) | EGLN1VEGFACASRSMN1; SMN2MEN1 | |
| SCHEMBL271606 | 0.83 | EGLN1 (1.00) | EGLN1VEGFACASRSMN1; SMN2MEN1 | |
| SCHEMBL17340697 | 0.75 | VEGFA (0.67) | EGLN1VEGFASMN1; SMN2 | |
| SCHEMBL3538788 | 0.75 | VEGFA (0.82) | EGLN1VEGFACASRMEN1KMT2A | |
| SCHEMBL17340661 | 0.73 | VEGFA (0.57) | EGLN1VEGFAMAPK14 | |
| SCHEMBL15314775 | 0.72 | KMT2A (0.47) | EGLN1VEGFASMN1; SMN2MEN1KMT2A | |
| SCHEMBL17340685 | 0.70 | EGLN1 (0.50) | EGLN1VEGFAMAPK14 | |
| SCHEMBL6693007 | 0.70 | VEGFA (0.55) | EGLN1VEGFASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9732459 | 0.69 | KMT2A (0.59) | EGLN1VEGFASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2954899-A1 | COMPOSITIONS AND METHODS FOR TREATING COLITIS | Aerpio Therapeutics, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |